raw 264.7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1546	Dactylorhin A		NO Synthase
	Dactylorhin A, a succinate derivative ester isolated from the rhizomes of Gymnadenia conopsea, demonstrates a moderate inhibitory effect on nitric oxide (NO) production in RAW 264.7 macrophage cells.		NO Synthase
TN2167	Rutaevin		Reactive Oxygen Species , NO Synthase
	Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.		Reactive Oxygen Species , NO Synthase
T8705	BOT-64		IκB/IKK
	BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound		IκB/IKK
T15102	Dexamethasone palmitate	DXP	Glucocorticoid Receptor
	Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an...		Glucocorticoid Receptor
TN1118	Tormentic acid		Immunology/Inflammation related
	Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,		Immunology/Inflammation related
T9862	Pseudocoptisine chloride	Isocoptisine chloride	AChE
	Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μ...		AChE
T1209	Flunixin meglumine	Banamine,Finadyne,Flunixin meglumin	COX
	Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.		COX
T8550	NDMC101		Others , NF-κB , Proteasome
	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.		Others , NF-κB , Proteasome
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T2758	Madecassic acid	6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose	Others , TNF , COX , NO Synthase , Interleukin
	Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.		Others , TNF , COX , NO Synthase , Interleukin
TN1291	7,3',4'-Tri-O-methylluteolin	5-Hydroxy-3',4',7-trimethoxyflavone	TNF , COX , Interleukin
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml		TNF , COX , Interleukin
TN1818	Kaempferol 3-O-β-D-glucuronide	Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide	IL Receptor
	Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.		IL Receptor
T4543	Telithromycin	HMR3647,Ketek,RU66647	Antibacterial , Antibiotic
	Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis...		Antibacterial , Antibiotic
T22698	TLR3-IN-1	CU CPT 4a	TLR
	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...		TLR
T2S0765	Epibetulinic acid		NO Synthase , Prostaglandin Receptor
	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.		NO Synthase , Prostaglandin Receptor
T13686	Ergolide		NF-κB
	Ergolide, a sesquiterpene lactone extracted from the dried flowers of Inula Britannica, effectively hinders the expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in RAW 264.7 macrophages by deactivating...		NF-κB
TN4228	Hulupinic acid		NO Synthase
	Hulupinic acid is the main oxidation product of hop acid, which may inhibit the production of NO in macrophages RAW 264.7 cells.		NO Synthase
T10341	Antitumor agent-19		Others
	Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.		Others
T4951	Kauran-16,17-diol		Apoptosis , Others
	Kauran-16,17-diol, a natural diterpenoid product, exhibits anti-tumoral and apoptosis-inducing activities by inhibiting NO production in LPS-induced RAW 264.7 cells with an IC50 value of 17 μM.		Apoptosis , Others
T64359	Anti-inflammatory agent 36		Immunology/Inflammation related
	Anti-inflammatory agent 36 is an anti-inflammatory agent. It exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages, IC50=3.69uM and 3.68uM, respectively.		Immunology/Inflammation related